Chub can be made to eat bombs to damage her, just like the Dodongo.The Stepladder from the original Zelda's functionally identical counter-part, simply called 'The Ladder.'.

Wrath of the Lamb's candle is pulled straight from The Legend of Zelda.

Teleportation items may randomly send you to a room with a guy saying ' I AM ERROR.'.

Rebirth added Mom's Hands (which behave like Wallmasters) and Bonies (which behave like Stalfos).

The most noticeable are the Chargers (which behave like Ropes), Knights (which behave like Darknuts), and Pokys (which behave like Traps).

Many enemies are also reminiscent of Zelda enemies.

In Rebirth, alternate trapdoors can send you to underground rooms that are just as blatant.

The HUD and basic rooms are very blatant ones to The Legend of Zelda.

The Japanese logo for Rebirth is instead a parody of the logo for The Legend of Zelda: A Link to the Past, with a pentagram replacing the Tri-Force.

The game's logo is very reminiscent of the first game's.

Repentance adds the Mega Mush, and just like the Mega Mushroom, it turns Isaac gigantic and allows him to defeat nearly every enemy just by running into them.

Collecting enough mushrooms in Afterbirth turns you into a mushroom-person, strikingly similar to a Toad.

One of the messages dispensed from the Fortune Teller is 'Your princess is in another castle'.

The description of the Liberty Cap is ' Touch fuzzy, get dizzy'.

Rebirth has an item called Gnawed Leaf that gives Isaac a raccoon tail and lets him turn into a statue.

What does it look like? A copy of the original Super Mario Bros.

One of Rebirth's items allows you to jump.

The Bobby-Bomb walking bomb upgrade is a clear reference to Bob-Omb.

The Magic Mushroom and the Mini Mush are direct references to Mario's Super Mushroom and Mini Mushroom.

The 1-up mushroom that follows you around is green with white spots.

Touch fuzzy get dizzy music